RCT supports plantarum probiotic’s anti-obesity effects

Twelve weeks of supplementation with Lactiplantibacillus plantarumsubsp. plantarum​ LMT1-48 (formerly known as Lactobacillus plantarumLMT1-48) also led to improvements in body mass index and insulin resistance in a randomized, double-blind, placebo-controlled clinical trial with 100 overweight volunteers.

“Our data regarding the gut microbiota is largely in agreement with other studies showing that the gut microbiota play key roles in human energy metabolism and the pathogenesis of obesity,” ​wrote scientists from Seoul National University College of Medicine and Medytox in Diabetes & Metabolism Journal.

“They also support the idea that interventions to manipulate the gut microbiome with probiotics have a great therapeutic potential for alleviating obesity and obesity-related diseases.”

Gut microbiota and obesity

The link between the gut microbiota and obesity was first reported in 2006 by Jeffrey Gordon and his group at Washington University in St. Louis, who found that microbial populations in the gut are different between obese and lean people, and that when the obese people lost weight their microflora reverted back to that observed in a lean person. This suggested that obesity has a microbial component (Nature​, Vol. 444, p. 1022-1023, 1027-1031​).

A 2013 paper in Science​​ (Vol. 341, Issue 6150), also led by Prof Gordon, found that transplanting gut bacteria from obese humans into germ-free mice leads to greater weight gain and fat accumulation than mice that were given bacteria from the guts of lean humans .


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